Career Center

Post-doctoral researcher position available in the van den Brink Lab

Research Area: Generation and evaluation of CAR T cells engineered to treat multiple myeloma.

The van den Brink lab at Memorial Sloan Kettering Cancer Center is looking for a highly motivated post-doc to work on a project involving novel T cell immunotherapies for multiple myeloma. Our lab focuses on a variety of research topics related to cancer immunotherapy, including hematopoietic stem cell transplantation, graft-versus-host disease, effects of the microbiota on transplant outcomes, immune reconstitution/thymic rejuvenation strategies, and CAR T cell therapy for various malignancies.

The CAR T cell group of the van den Brink lab designs novel CAR T cells targeting hematologic malignancies with the goal of improving T cell activity while reducing toxicities. We study CAR T cell activity in syngeneic mouse models and are currently developing xenograft mouse models. This postdoc position will focus on developing next-generationCAR T cells targeting human myeloma antigens with the goal of translating these CAR T cells into clinical application.

Lab Website: https://www.mskcc.org/research/ski/labs/marcel-van-den-brink

Responsibilities:
human T cell cultures and viral transduction
in vitro cell proliferation, protein expression, cell viability, immunophenotyping, and cytoxicity assays
CRISPR/Cas9 and gene transfer
Generation and maintenance of tumor cell lines and virus producing-packaging lines in culture
Xenograft models of human myeloma in mice
Mouse handling, injection, and harvesting tissues
Multi-color flow cytometry
Molecular cloning of CAR constructs

Qualifications:
PhD, MD/PhD, or MD completed in cancer immunology, immunotherapy, T cell biology, cell engineering, or related field
Excellent verbal and written communication skills
Solid publication record
Experience will mammalian cell culture and aseptic techniques is essential
Experience with retroviral/lentiviral human T cell transduction methods is preferred
Experience with multi-color flow cytometry panels is preferred
Experience with mouse handling and procedures is advantageous, but not required

Accommodation:
The van den Brink lab is located in the Mortimer B. Zuckerman Research Center of the Sloan Kettering Institute of MSKCC.
It is part of the Immunology Program. MSKCC combines laboratories with a focus on basic as well as cancer research.
MSKCC is located in a vibrant hub of world-renowned biomedical research institutions in New Yorks Upper East Side,
adjacent to Rockefeller University and the Weill Cornell Medical College. The vast resources within MSKCC and these
surrounding institutions will help to facilitate the success of the applicants projects and enable to establish collaborations
with other laboratories.
Salary is competitive and commensurate with experience. MSKCC offers dedicated housing for postdoctoral fellows. This
is a 2-year appointment with possibility of renewal for up to 5 years based upon satisfactory job performance, continuing
availability of funds, and ongoing operational needs.

To apply:
Applicants should submit their CV, a letter outlining interest and motivations and names and contact information of three
references.

#LIPOST